Is CpG an adjuvant?
When used as vaccine adjuvants, CpG ODNs improve the function of professional antigen-presenting cells and boost the generation of humoral and cellular vaccine-specific immune responses. These effects are optimized by maintaining ODNs and vaccine in close proximity.
Do DNA vaccines need adjuvants?
Since in mice DNA vaccines are usually quite immunogenic and do not need a significant enhancement by adjuvants, these data obtained are not directly transferable to larger animal species.
What does CpG adjuvant stand for?
CpG oligodeoxynucleotides (or CpG ODN) are short single-stranded synthetic DNA molecules that contain a cytosine triphosphate deoxynucleotide (“C”) followed by a guanine triphosphate deoxynucleotide (“G”).
What is the adjuvant CpG 1018?
CpG 1018 is the adjuvant contained in HEPLISAV-B®, the Company’s U.S. FDA-approved hepatitis B vaccine.
What is CpG oligo?
CpG-oligodeoxynucleotides (ODN) is a short synthetic DNA containing unmethylated CpG motifs, highly prevalent in bacterial DNA, and recognized by Toll-like receptor 9 (TLR9), which is expressed by a variety of cells in the immune system.
Why are DNA vaccines better?
The main advantage of DNA vaccines is their ability to stimulate both the humoral and cellular arms of the adaptive immune system. In regards to humoral immunity, the generation of antibodies by B lymphocytes against invading pathogens is one of the most effective defenses mounted by the immune system.
What is the role of adjuvants in vaccination?
An adjuvant is an ingredient used in some vaccines that helps create a stronger immune response in people receiving the vaccine. In other words, adjuvants help vaccines work better.
Why adjuvants are used in vaccine?
What is CpG DNA?
Definition. CpG is shorthand for 5’—C—phosphate—G—3′ , that is, cytosine and guanine separated by only one phosphate group; phosphate links any two nucleosides together in DNA. The CpG notation is therefore to be interpreted as the cytosine being 5 prime to the guanine base.
